First systematic description of gingival grafting, including healing mechanisms, and set the foundation for modern soft tissue grafting techniques ...
Read detailsLandmark study that demonstrated that connective tissue dictates the phenotype of overlying epithelium in the oral mucosa.
Read detailsIntroduction of the concept of "compartmentalization" in the literature, which was fundamental for the development of periodontal regenerative ther...
Read detailsA histological investigation of human periodontal tissues following reattachment procedures provided critical insight into the healing and reformat...
Read detailsA comparative histological study evaluating the influence of four different regenerative procedures on connective tissue attachment levels highligh...
Read detailsAn early experimental study assessing the healing potential of periodontitis-affected roots implanted into bone revealed that diseased tissues reta...
Read detailsOne of the first clinical studies in humans to clearly report new attachment formation following surgery, this study provided early clinical valida...
Read detailsA landmark paper that explicitly introduced the term Controlled Tissue Regeneration, demonstrating that tissue healing could be actively regulated ...
Read detailsA follow-up in vivo study providing experimental evidence for Melcher’s hypothesis, confirming that PDL cells can guide true regeneration of period...
Read detailsOne of the earliest clinical case reports applying GTR in humans, demonstrating that barrier membranes can promote new attachment formation, thereb...
Read detailsA landmark histological study confirming that new cementum, PDL, and bone could form following GTR in humans, offering definitive biological proof ...
Read detailsThe first animal study to successfully apply GTR principles to bone defects rather than the periodontium, representing the origin of the concept of...
Read detailsA pivotal human study evaluating multiple surgical regenerative techniques, verifying their ability to reconstitute the full new attachment apparat...
Read detailsA clinical case series applying the GBR concept to peri-implant bone defects, helping establish GBR as the standard approach for pre-implant bone r...
Read detailsA classic study highlighting the importance of wound stability, particularly the blood clot,s for regenerative success.
Read detailsAn experimental study describing the bone healing pattern,confirming the original hypothesis of GBR that membrane coverage of bone defects creates ...
Read detailsThe study evaluated bone and cementum regeneration following periodontal reconstructive surgery using recombinant human bone morphogenetic protein-...
Read detailsThe first pivotal clinical trial demonstrating the effectiveness of Enamel Matrix Derivative (EMD/EMDOGAIN®) in humans, marking a shift from physic...
Read detailsOne of the earliest clinical studies comparing biodegradable collagen membranes versus ePTFE membrane.
Read detailsOne of the first controlled clinical trials to directly compare GTR and EMD under the same conditions, providing valuable evidence for selecting be...
Read detailsThe paper explains the roles of different cells—like fibroblasts, immune cells, and epithelial cells—in tissue health, inflammation, healing, and p...
Read detailsThe first human histological evidence of new connective tissue attachmentn following root coverage with a subepithelial connective tissue graft, co...
Read detailsThis study demonstrated that subepithelial connective tissue grafts undergo rapid and complete revascularization from the periodontal and supraperi...
Read detailsA landkmark paper describing the healing sequence that leads to implant osseointegration.
Read detailsPreclinical histological evidence showing periodontal regeneration—including new cementum with inserting collagen fibers and significant bone fill—...
Read detailsThe first human histological evidence that the use of rhPDGF-BB combined with bone allograft promotes periodontal regeneration in Class II furcatio...
Read detailsA landmark paper describing the healing sequence that leads to implant osseointegration on different implant surfaces.
Read detailsThis study laid the groundwork for biologically advanced, cell-based regenerative therapies beyond conventional biomaterials or growth factors.
Read detailsOne of the preclinical studies supporting the use of rhBMP for enhanced bone formation.
Read detailsOne of the earliest preclinical studies demonstrating thin buccal bone wall undergoes rapid resorption with over 2 mm of vertical loss after tooth ...
Read detailsAn animal study confirming that periodontal healing following GTR in recession-type defects can lead to long-term complete periodontal regeneration.
Read detailsA foundational study showing that tooth extraction is not merely a surgical procedure but a biological turning point, emphasizing the importance of...
Read detailsAn in vitro study showing that mesenchymal stem cells derived from inflamed periodontal ligaments have impaired immunomodulatory function, highligh...
Read detailsAn in vivo study investigating how different autogenous bone harvesting techniques influence the release of growth factors.
Read detailsPreclinical study demonstrating that implantation of cementum- or PDL-derived cells promotes true periodontal regeneration, including new cementum ...
Read detailsThis study provides a detailed temporal mapping of early periodontal wound healing and regeneration, clarifying the rapid cellular events that shap...
Read detailsThe impact of immune cells on bone regeneration is presumably a way to reinitiate the developmental mechanisms of intramembranous and endochondral ...
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