Guided Bone Regeneration

Landmark experimental study demonstrating the generation of new bone around titanium implants using a membrane technique.

This is one of the first systematic reviews that discussed the different factors affecting healing with stage I or stage II GBR procedures but also indicated that we can draw (at that time) limited conclusions regarding the success of the augmentation and its effect on the survival of the implants.

This study combined, for the first time, different 'omics' outputs to identify new insights on the molecular mechanisms related to (implant) surface hydrophilicity during osseointegration and bone regeneration. In this paper, specific signalling pathways were identified as differentially modulated by titanium surface hydrophilicity. These findings may be used in the future explain some of the biologic process that we apply in the clinic in this field.

This is a comprehensive review on the mechanisms controlling membrane-host interactions in guided bone regeneration (GBR) where also the wider role of membranes as bioactive compartments in addition to their established role as barriers is discussed.

The aim of this systematic review was to analyse the evidence in relation to the efficacy of lateral bone augmentation procedures in terms of defect resolution in cases of horizontal ridge deficiencies after implant placement. In this review, the reader can find clarification on the efficacy of the GBR procedure and the influence of various biomaterials on short- and longer-term outcomes.