Peri-Implantitis

1980s
1987
Mombelli et al
1987

First use of the term “peri-implantitis” and description of the microbiota associated with the disease

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1989
Gammage et al
1989

One of the first reports describing the indication of a free gingival graft before reconstructive therapy with allograft and a non-submerged healing approach

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1990s
1990
Lozada et al
1990

One of the first publications on combined surgical therapy, including implantoplasty and allograft-based reconstruction

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1992
Meffert
1992

One of the first descriptions of reconstructive therapy using allograft with a non-submerged healing approach

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1992
Mombelli & Lang
1992

First report on the use of antibiotics as an adjunct to non-surgical peri-implantitis therapy

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1992
Zablotsky
1992

One of the first publications on reconstructive therapy using allograft and a non-resorbable membrane with a submerged healing approach

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1995
Hammerle et al
1995

One of the first publications on reconstructive therapy using a non-resorbable membrane with a non-submerged healing approach

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1995
Melloning et al
1995

One of the first publications on reconstructive therapy using allograft or alloplastic bone grafts combined with a non-resorbable membrane, with either a non-submerged or submerged healing approach

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1997
Lang et al
1997

Description of Cumulative Interceptive Supportive Therapy (CIST) for the management of biological complications

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1999
Muller et al
1999

One of the first case reports applying implantoplasty as a mechanical method for implant surface decontamination

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2000s
2000
Bach et al
2000

Clinical study comparing the use vs. non-use of a diode laser for implant surface decontamination before resective and/or reconstructive surgery

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2000
Behneke et al
2000

One of the first publications on reconstructive therapy using particulate or block autogenous bone grafts with a non-submerged healing approach

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2000
Lang et al
2000

Description of Cumulative Interceptive Supportive Therapy (CIST) for the management of biological complications

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2001
Deporter & Todescan Jr
2001

One of the first publications on reconstructive therapy using allograft and a resorbable membrane with a non-submerged healing approach

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2001
Khoury & Buchmann
2001

One of the first publications on reconstructive therapy using particulate or block autogenous bone grafts combined with a non-resorbable or resorbable membrane, with either a non-submerged or submerged healing approach

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2001
Mombelli et al
2001

Case series showing the effect of non-surgical therapy consisting of mechanical debridement followed by local antibiotic application

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2004
Renvert et al
2004

Randomized controlled trial comparing the local application of chlorhexidine or minocycline as an adjunct to non-surgical therapy

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2005
Karring et al
2005

RCT comparing mechanical debridement using carbon-fiber curettes with an ultrasonic carbon-fiber tip combined with an aerosol spray during non-surgical therapy

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2005
Romeo et al
2005

Randomized controlled trial comparing resective surgery with or without implantoplasty for the treatment of peri-implantitis

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2005
Schwarz et al
2005

First randomized controlled trial comparing the effectiveness of Er:YAG laser therapy with mechanical debridement for the non-surgical treatment of peri-implantitis

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2006
Schwarz et al
2006

One of the first publications on reconstructive therapy using alloplastic or xenograft combined with a collagen membrane and a non-submerged healing approach

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2007
Schwarz et al
2007

Proposal of a morphology-based classification of peri-implant bone defects

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2009
Renvert et al
2009

RCT comparing two non-surgical mechanical debridement methods, titanium hand instruments and an ultrasonic device, both showing limited impact on disease resolution

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2009
Serino & Ström
2009

Cross-sectional study showing the correlation between peri-implantitis and limited accessibility for oral hygiene

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2010s
2010
Schwarz et al
2010

Prospective clinical study showing that defect configuration may influence clinical outcomes following surgical regenerative therapy

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2011
Renvert et al
2011

RCT comparing mechanical debridement using an Er:YAG laser or an air-abrasive device with glycine powder during non-surgical therapy

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2011
Roccuzzo et al
2011

One of the first reports describing the use of a connective tissue graft in selected cases during reconstructive therapy

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2011
Schwarz et al
2011

One of the first report of the so-called “combined surgical therapy”

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2011
Serino & Turri
2011

Prospective study on the outcomes of resective surgical therapy (pocket elimination and bone recontouring) followed by a strict maintenance protocol over a 2-year follow-up period

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2012
Heitz-Mayfield et al
2012

Description of the "anti-infective protocol" for the treatment of peri-implantitis

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2014
Schwarz et al
2014

One of the first clinical studies demonstrating the benefits of adding a connective tissue graft during the surgical treatment of peri-implantitis

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2014
Schwarz et al
2014

Case report describing the use of a soft tissue substitute during combined surgical therapy

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2015
Serino et al
2015

Prospective study demonstrating the impact of a maintenance protocol after five years of resective surgery for the treatment of peri-implantitis

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2016
Canullo et al
2016

Retrospective study showing a strong association between surgical factors and the diagnosis of peri-implantitis

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2016
Carcuac et al
2016

RCT assessing the adjunctive effect of systemic antibiotics and local chlorhexidine use for implant surface decontamination during the surgical treatment of peri-implantitis

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2016
Derks et al
2016

Landmark clinical paper on the epidemiology of peri-implantitis in a Swedish population

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2017
Roccuzzo et al
2017

Prospective case series with a 7-year follow-up after reconstructive therapy using DBBM and a collagen membrane

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2018
Berglundh et al
2018

Long-term outcomes after resective surgical treatment of peri-implantitis

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2018
Berglundh et al
2018

Consensus report on peri-implant diseases and conditions from the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions

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2018
Heitz-Mayfield et al
2018

Prospective study demonstrating the impact of a maintenance protocol after five years of surgical treatment by access surgery

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2018
Renvert et al
2018

Case definition of peri-implantitis based on the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions

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2018
Renvert et al
2018

RCT evaluating the use vs. non-use of a bone substitute in three- or four-wall peri-implantitis defects

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2019
Monje et al
2019

Proposal of a morphology-based classification of peri-implant bone defects

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2019
Schlee et al
2019

First RCT comparing mechanical implant surface decontamination with or without electrolytic cleaning

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2020s
2020
Monje et al
2020

Prospective case series demonstrating the benefits of a free gingival graft as part of surgical therapy

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2022
Derks et al
2022

Multicenter RCT assessing the potential benefit of the use of a bone substitute material in the reconstructive surgical therapy

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2023
Monje et al
2023

RCT comparing the use vs. non-use of a collagen membrane during reconstructive therapy

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2025
Garaicoa-Pazmiño et al
2025

Systematic review showing that disease resolution after treatment of peri-implant diseases is generally unpredictable and infrequently achieved

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2025
Isler et al
2025

RCT with long-term follow-up evaluating reconstructive therapy using a bone substitute combined with either concentrated growth factors or a collagen membrane

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2025
Monje et al
2025

Multicenter RCT assessing the effect of an electrolytic method for implant surface decontamination during reconstructive therapy

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2025
Ravida et al
2025

Description of the Biological Reset Protocol for the regenerative treatment of peri-implantitis

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2026
Park et al
2026

RCT comparing implantoplasty with rotating titanium brushes for implant surface decontamination

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2026
Zhou et al
2026

Retrospective analysis reporting the treatment outcomes of different surgical protocols for peri-implantitis

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