Tissue Engineering

1990s
1993
Langer & Vacanti
1993

Introduction of the concept of "tissue engineering" in the literature.

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1997
Heijl et al
1997

RCT evaluating the use of EMD in hydrogel carrier for periodontal regeneration.

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1997
Howell et al
1997

First clinical trial of PDGF/IGF-1 in hydogel vehicle for periodontal regeneration in human.

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1998
Yukna et al
1998

RCT evaluating the use of a synthetic cell-binding peptide (P-15) with xenogenic bone graft for periodontal regeneration.

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2000s
2000
Bartold et al
2000

Seminal review introducing concept of tissue engineering for periodontal regeneration.

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2000
van der Bergh et al
2000

Case series applying OP-1 in a collagen carrier for sinus floor augmentation procedures.

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2003
Nevins et al
2003

First report of periodontal regeneration of class II furcation defects using an allogenic bone graft substitute saturated with rhPDGF-BB.

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2003
Pini-Prato et al
2003

Case series of gingival augmentation procedures using an autogenous hyaluronic acid-enriched cell graft.

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2003
Wiltfang et al
2003

RCT evaluating the use of PRP with alloplastic bone graft substitute for sinus floor augmentation procedures.

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2004
Seo et al
2004

First identification and characterization of periodontal ligament stem cells in human teeth.

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2005
Boyne et al
2005

RCT evaluating the effect of rhBMP-2 delivered in a collagen sponge for maxillary sinus floor augmentation.

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2005
Fiorellini et al
2005

RCT evaluating the use of rhBMP-2 in a collagen carrier for alveolar ridge reconstruction.

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2005
McGuire & Nunn
2005

RCT evaluating the performance of a living tissue-engineered human fibroblast-derived dermal substitute for keratinized tissue augmentation around ...

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2005
Nevins et al
2005

Multicenter RCT evaluating the use of rhPDGF-BB combined with an alloplastic bone graft substitute for periodontal regeneration.

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2005
Wilson Jr et al
2005

RCT evaluating a living tissue-engineered human fibroblast-derived dermal substitute for root coverage.

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2007
Mohammadi et al
2007

RCT evaluating the use of a collagen scaffold containing cultured autogenous fibroblasts for gingival augmentation.

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2009
Mangano et al
2009

Use of autogenous osteoblasts seeded on a polyglycolic-polylactic scaffold for sinus floor augmentation.

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2009
d'Aquino et al
2009

First study reporting bone regeneration in humans following the application of a collagen sponge with dental pulp stem/progenitor cells.

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2010s
2010
Feng et al
2010

Case series of periodontal regeneration using autologous periodontal ligament progenitor cells in an alloplastic bone substitute carrier.

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2010
Jhaveri et al
2010

Case series of root coverage procedures utilizing an acellular dermal matrix seeded with autologous gingival fibroblasts.

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2011
McGuire et al
2011

Multicenter RCT testing a collagen matrix seeded with allogeneic keratinocytes and dermal fibroblasts for enhancing keratinized tissue around teeth.

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2011
Nevins et al
2011

RCT evaluating the use of rhPDGF-BB or EMD with xenogenic bone graft substitute in alveolar ridge reconstruction.

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2013
Froum et al
2013

RCT assessing rhPDGF in combination with a xenogenic bone graft substitute for sinus floor augmentation procedures.

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2013
Kaigler et al
2013

RCT evaluating the use of CD90+ stem cells and CD14+ monocytes applied to a gelatin sponge in alveolar ridge preservation.

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2013
de Freitas et al
2013

RCT evaluating rhBMP-2 delivered in an absorbable collagen sponge carrier for horizontal ridge augmentation.

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2014
Ivanovski et al
2014

Review of multiphasic scaffolds for compartmentalized tissue engineering to promote periodontal regeneration.

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2015
Kaigler et al
2015

RCT applying alloplastic bone graft substitute enriched with CD90+ stem cells and CD14+ monocytes for sinus augmentation procedures.

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2015
Rasperini et al
2015

First case report illustrating the use of 3D-printed scaffolds with rhPDGF-BB for periodontal reconstruction.

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2015
Santana & Santana
2015

RCT assessing an alloplastic bone graft substitute combined with rhPDGF-BB for horizontal bone augmentation.

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2016
Chen et al
2016

RCT applying a xenogenic bone graft subtitute with autologous periodontal ligament stem cells for periodontal regeneration of intrabony defects.

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2017
Sangiorgio et al
2017

RCT evaluating the use of a collagen matrix with EMD for treating gingival recession.

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2018
Clark et al
2018

RCT evaluating the use of A-PRF with allogenic bone graft substitute for alveolar ridge preservation.

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2018
Ferrarotti et al
2018

RCT using a collagen sponge scaffold complexed with autogenous dental pulp micrografts for periodontal regeneration of deep intrabony defects.

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2018
Mercado et al
2018

Case series evaluating the use of EMD, xenogenic bone graft substitute, and doxycycline for the treatment of peri-implantitis.

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2018
Thoma et al
2018

RCT evaluating the use of xenogeneic bovine bone blocks loaded with rhBMP-2.

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2020s
2020
Lee et al
2020

RCT evaluating the use of EMD with a collagenated xenogenic bone graft for alveolar ridge preservation.

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2020
Sanchez et al
2020

RCT evaluating autologous periodontal ligament-derived mesenchymal stem cells embedded in a xenogeneic bone substitute for the regenerative treatme...

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2021
Lin et al
2021

RCT evaluating the use of CGF with xenogenic bone graft in alveolar ridge preservation.

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2022
Jung et al
2022

Seventeen-year follow-up of an RCT testing rhBMP-2 combined with a xenogenic bone graft substitute for horizontal ridge augmentation.

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2022
Pilenza et al
2022

Case series evaluating the use of EMD and xenogenic bone graft substitute for the treatment of peri-implantitis.

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2022
Tavelli et al
2022

RCT evaluating the use of a cross-linked collagen matrix with rhPDGF-BB for the treatment of multiple gingival recessions.

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2023
Tavelli et al
2023

Thirteen-year follow-up of an RCT testing a collagen matrix seeded with allogeneic keratinocytes and dermal fibroblasts to enhance keratinized tiss...

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2024
Ivanovski et al
2024

Case report on the use of a 3D-printed patient-specific scaffold combined with iPRF with xenogenic bone graft substitute and autogenous bone graft ...

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2024
Ivanovski et al
2024

Contemporary review of clinical trials using dental mesenchymal stem cells.

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