Minimally Invasive Surgical Therapy

1980s
1986
Tatum
1986

Description of the osteotome sinus floor elevation

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1990s
1992
Scharf & Tarnow
1992

Clinical report describing the roll technique to improve ridge contour avoiding a second surgical site

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1994
Allen
1994

First description of the tunnel technique for root coverage

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1995
Harrel & Rees
1995

Description of the Minimally Invasive Surgery (MIS) approach in periodontology

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1999
Rasperini et al
1999

First cases of periodontal regeneration with the use of amelogenins

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2000s
2001
Cortellini & Tonetti
2001

Landmark clinical study on the use of an operating microscope in periodontal regeneration

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2005
Burkhardt & Lang
2005

Key publication comparing microsurgical and macrosurgical techniques for root coverage procedures

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2007
Cortellini & Tonetti
2007

Introduction of the minimally invasive surgical technique (MIST) for intrabony periodontal defects

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2009
Cortellini & Tonetti
2009

Description of the modified minimally invasive surgical technique (M-MIST) for intrabony defects

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Trombelli et al
2009

Description of a new minimally invasive technique, the single flap approach

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2010s
2011
Ribeiro et al
2011

First RCT comparing MIST to MIST+EMD

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Zadeh
2011

Description of the VISTA technique

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2012
Avila-Ortiz et al
2012

First paper to assess the impact of lateral window dimensions on bone formation outcomes

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2014
Zucchelli et al
2014

RCT describing the impact of the connective tissue graft size on patient morbidity and surgery outcomes

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2017
Baldini et al
2017

RCT assessing the benefits of minimally invasive procedures for sinus floor elevation

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2020s
2021
Cortellini et al
2021

5-year case series: periimplantitis treatment with papilla preservation flap and minimally invasive surgery

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2024
Carrillo de Albornoz et al
2024

Retrospective study evaluating flapless surgical approach for peri-implantitis treatment

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2025
Sirinirund et al
2025

First RCT assessing the benefits of using an operating microscope for alveolar ridge preservation

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